Is honey effective in reducing pain for people who had tonsillectomy?

OBJECTIVE: The objective of this selective evidence based medicine (EBM) review is to determine whether or not “Is honey is effective in reducing pain for people who had tonsillectomy?” STUDY DESIGN: Review two randomized control trials and one cohort study published in English between 2009 and 2019. DATA SOURCES: Two randomized control trials and one cohort study were found using PubMed databases. OUTCOMES MEASURED: The primary outcome measured was the pain intensity after tonsillectomy. The study by Mohebbi et al. and Hatami et al. used visual analog scale (VAS) and the study by Abdullah et al. used the facial pain scale for patients under 7 years old and VAS for patients above 7 years old. RESULTS: One randomized control trial (RCT) comparing honey to cephalexin, one RCT comparing honey to sultamicillin, and one cohort study comparing honey to tramadol. In a RCT by Mohebbi et al., there was a significant reduction in pain between honey and cephalexin. In a RCT by Abdullah et al. illustrated that the p-value was 0.655 indicating the result was not significant. The cohort study by Hatami et al. showed that the p-value was greater than 0.05 indicating the result was not significant. CONCLUSIONS: There were conflicting data in assessing the efficacy of honey in reducing pain for people who had tonsillectomy. In order to evaluate whether honey can significantly reduce pain, there needs to be more reliable studies that include larger sample size, or different types of honey

Intermediate-mass black holes in dwarf galaxies out to redshift ∼\sim 2.4 in the Chandra COSMOS Legacy Survey

We present a sample of 40 AGN in dwarf galaxies at redshifts $z \lesssim$ 2.4. The galaxies are drawn from the \textit{Chandra} COSMOS-Legacy survey as having stellar masses $10^{7}\leq M_{*}\leq3 \times 10^{9}$ M$_{\odot}$. Most of the dwarf galaxies are star-forming. After removing the contribution from star formation to the X-ray emission, the AGN luminosities of the 40 dwarf galaxies are in the range $L_\mathrm{0.5-10 keV} \sim10^{39} - 10^{44}$ erg s$^{-1}$. With 12 sources at $z > 0.5$, our sample constitutes the highest-redshift discovery of AGN in dwarf galaxies. The record-holder is cid\_1192, at $z = 2.39$ and with $L_\mathrm{0.5-10 keV} \sim 10^{44}$ erg s$^{-1}$. One of the dwarf galaxies has $M_\mathrm{*} = 6.6 \times 10^{7}$ M$_{\odot}$ and is the least massive galaxy found so far to host an AGN. All the AGN are of type 2 and consistent with hosting intermediate-mass black holes (BHs) with masses $\sim 10^{4} - 10^{5}$ M$_{\odot}$ and typical Eddington ratios $> 1\%$. We also study the evolution, corrected for completeness, of AGN fraction with stellar mass, X-ray luminosity, and redshift in dwarf galaxies out to $z$ = 0.7. We find that the AGN fraction for $10^{9}< M_{*}\leq3 \times 10^{9}$ M$_{\odot}$ and $L_\mathrm{X} \sim 10^{41}-10^{42}$ erg s$^{-1}$ is $\sim$0.4\% for $z \leq$ 0.3 and that it decreases with X-ray luminosity and decreasing stellar mass. Unlike massive galaxies, the AGN fraction seems to decrease with redshift, suggesting that AGN in dwarf galaxies evolve differently than those in high-mass galaxies. Mindful of potential caveats, the results seem to favor a direct collapse formation mechanism for the seed BHs in the early Universe.Comment: 16 pages, 10 figures, accepted for publication in MNRA

A quasi-time-dependent radiative transfer model of OH104.9+2.4

We investigate the pulsation-phase dependent properties of the circumstellar dust shell (CDS) of the OH/IR star OH104.9+2.4 based on radiative transfer modeling (RTM) using the code DUSTY. Our previous study concerning simultaneous modeling of the spectral energy distribution (SED) and near-infrared (NIR) visibilities (Riechers et al. 2004) has now been extended by means of a more detailed analysis of the pulsation-phase dependence of the model parameters of OH104.9+2.4. In order to investigate the temporal variation in the spatial structure of the CDS, additional NIR speckle interferometric observations in the K' band were carried out with the 6 m telescope of the Special Astrophysical Observatory (SAO). At a wavelength of 2.12 micron the diffraction-limited resolution of 74 mas was attained. Several key parameters of our previous best-fitting model had to be adjusted in order to be consistent with the newly extended amount of observational data. It was found that a simple rescaling of the bolometric flux F_bol is not sufficient to take the variability of the source into account, as the change in optical depth over a full pulsation cycle is rather high. On the other hand, the impact of a change in effective temperature T_eff on SED and visibility is rather small. However, observations, as well as models for other AGB stars, show the necessity of including a variation of T_eff with pulsation phase in the radiative transfer models. Therefore, our new best-fitting model accounts for these changes.Comment: 7 pages, including 5 postscript figures and 3 tables. Published in Astronomy and Astrophysics. (v1: accepted version; v2: published version, minor grammatical changes

Centering High Risk Pregnancies Interprofessionaly (CHRPI) to Reduce Racial Disparities in Pregnancy Outcomes

Background: Despite the steady rise in use of prenatal care, significant racial disparities exist in pregnancy-related outcomes. This calls for innovative prenatal care to improve pregnancy outcomes in racial minorities. CHRPI is an innovative prenatal care model designed to address risk factors and manageable conditions particularly prevalent in African Americans that threaten their course of pregnancy. Methods: CHRPI is an outpatient model (Fig. 1) that will accept pregnant moms with risk-factors outlined by the ACOG. They are initially evaluated by a Maternal Fetal Medicine physician where management is outlined. Then, patients are placed in groups of 4 according to their expected course of pregnancy, social, and medical needs. Between medical appointments, patients will attend sessions facilitated by a multidisciplinary team to receive education on nutrition, insulin management, alarming symptoms and more. Additionally, patients will have opportunity to address individual social and medical needs with licensed clinical social workers and mid-level providers outside of groups. Lastly, CHRPI’s care extends as far as 6 months postpartum to reassess newly diagnosed conditions or risk-factors to protect future pregnancies and establish primary care upon exiting the program. Results: Compared to traditional care of high-risk patients (Fig. 2), proposed CHRPI model is expected to decrease rate of maternal and infant mortality, pre-term birth, NICU admissions, and patient satisfaction. Conclusion: CHRPI aims to reduce racial disparities in maternal and infant mortalities associated with high-risk pregnancies by utilizing an innovative multidisciplinary group approach with significant emphasis on nutrition, education, and primary care to protect future pregnancies.https://scholarscompass.vcu.edu/gradposters/1100/thumbnail.jp

Fracture toughness and crack-resistance curve behavior in metallic glass-matrix composites

Nonlinear-elastic fracture mechanics methods are used to assess the fracture toughness of bulk metallic glass (BMG) composites; results are compared with similar measurements for other monolithic and composite BMG alloys. Mechanistically, plastic shielding gives rise to characteristic resistance-curve behavior where the fracture resistance increases with crack extension. Specifically, confinement of damage by second-phase dendrites is shown to result in enhancement of the toughness by nearly an order of magnitude relative to unreinforced glass

Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial-mesenchymal transition in mice.

Growing evidence suggests close associations between periodontitis and atherosclerosis. To further understand the pathological relationships of these associations, we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/P.g. LPS) in Apolipoprotein E knock out mice and studied the atherogenesis process in these animals. The mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis, systemic inflammation, and atherosclerosis. Controls did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas, but mice receiving ligature or ligature/P.g. LPS showed severe periodontitis, systemic inflammation, and aortic plaque formation. The aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell markers. The severity of periodontitis was slightly higher in mice receiving ligature/P.g. LPS than ligature alone, and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/P.g. LPS. These observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe periodontitis. In vitro, P.g. LPS enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial cells. Moreover, secretory proteins, such as TNF-α, from macrophages induced endothelial-mesenchymal transitions of the endothelial cells. Taken together, systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via, in part, causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice